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A woman demonstrates the use of the OraQuick rapid HIV test. Blood being taken for HIV rapid test. Rapid antibody tests are qualitative immunoassays intended for use in point-of-care testing to aid in the diagnosis of HIV infection. These tests should be used in conjunction with the clinical status, history, and risk factors of the person being ...
HIV-associated neurocognitive disorders (HAND) are neurological disorders associated with HIV infection and AIDS.It is a syndrome of progressive deterioration of memory, cognition, behavior, and motor function in HIV-infected individuals during the late stages of the disease, when immunodeficiency is severe. [1]
It progresses rapidly, usually causing death within months of diagnosis. [25] HIV-associated dementia (HAD) is a metabolic encephalopathy induced by HIV infection and fueled by immune activation of HIV-infected brain macrophages and microglia. These cells are productively infected by HIV and secrete neurotoxins of both host and viral origin. [26]
Thus HIV infection can only be diagnosed by PCR testing for HIV RNA or DNA, or via testing for the p24 antigen. [30] Much of the world lacks access to reliable PCR testing, and people in many places simply wait until either symptoms develop or the child is old enough for accurate antibody testing. [113]
been diagnosed with Hodgkin's disease, non-Hodgkin's lymphoma, lymphocytic leukemia, multiple myeloma, or any cancer of lymphoreticular or histiocytic tissue, or angioimmunoblastic lymphoadenopathy; or been diagnosed with a genetic immunodeficiency syndrome atypical of HIV infection, such as one involving hypogammaglobulinemia.
Viral load tests can also be used to diagnose HIV infection, especially in children under 18 months born to mothers with HIV, where the presence of maternal antibodies prevents the use of antibody-based diagnostic tests. [8] Pooled viral RNA testing shortens the window period to a median of 17 days (95% CI, 13-28 Days). [9]
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