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Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
Doxylamine succinate is the active ingredient in many over-the-counter sleep aids branded under various names. Doxylamine succinate and pyridoxine (Vitamin B6) are the ingredients of Diclegis, approved by the FDA in April 2013 becoming the only drug approved for morning sickness [46] with a class A safety rating for pregnancy (no evidence of risk).
Co-treatment with vitamin B 6 alleviates the numbness. [8] Pyridoxine-dependent epilepsy is a type of rare infant epilepsy that does not improve with typical anti-seizure medications. [9] Pyridoxine in combination with doxylamine is used as a treatment for morning sickness in pregnant women. [10]
But antihistamines like promethazine, doxylamine, and diphenhydramine can interfere with your body temperature regulation and tamp down on your ability to sweat, according to the CDC. Stimulants
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Taking prenatal vitamins before pregnancy may decrease the risk. [3] Specific treatment other than a bland diet may not be required for mild cases. [2] [6] [3] If treatment is used the combination of doxylamine and pyridoxine is recommended initially. [3] [4] There is limited evidence that ginger may be useful.
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While pyridoxine/doxylamine, a combination of vitamin B 6 and doxylamine, is effective in nausea and vomiting of pregnancy, [43] some have questioned its effectiveness in HG. [ 44 ] Ondansetron may be beneficial, however, there are some concerns regarding an association with cleft palate, [ 45 ] and there is little high-quality data. [ 41 ]