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Several members of this subfamily have been described, and named GDF1 through GDF15. GDF1 is expressed chiefly in the nervous system and functions in left-right patterning and mesoderm induction during embryonic development. [2]
14559 Ensembl ENSG00000130283 ENSMUSG00000109523 UniProt P27539 P20863 RefSeq (mRNA) NM_001492 NM_001387438 NM_001163282 NM_008107 RefSeq (protein) NP_001483 NP_001156754 NP_032133 Location (UCSC) Chr 19: 18.87 – 18.9 Mb Chr 8: 70.78 – 70.78 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Growth differentiation factor 1 (GDF1) is a protein that in humans is encoded by the GDF1 ...
The transforming growth factor beta (TGFβ) receptors are a family of serine/threonine kinase receptors involved in TGF beta signaling pathway.These receptors bind growth factor and cytokine signaling proteins in the TGF-beta family such as TGFβs (TGFβ1, TGFβ2, TGFβ3), bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs), activin and inhibin, myostatin, anti-Müllerian ...
The transforming growth factor beta (TGF-β) superfamily is a large group of structurally related cell regulatory proteins that was named after its first member, TGF-β1, originally described in 1983. [2]
9518 23886 Ensembl ENSG00000130513 ENSMUSG00000038508 UniProt Q99988 Q9Z0J7 RefSeq (mRNA) NM_004864 NM_011819 NM_001330687 RefSeq (protein) NP_004855 NP_001317616 NP_035949 Location (UCSC) Chr 19: 18.37 – 18.39 Mb Chr 8: 71.08 – 71.09 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Growth/differentiation factor 15 is a protein that in humans is encoded by the GDF15 gene. GDF15 ...
The R-Smads consist of Smad1, Smad2, Smad3, Smad5 and Smad8/9, [3] and are involved in direct signaling from the TGF-B receptor. [4]Smad4 is the only known human Co-Smad, and has the role of partnering with R-Smads to recruit co-regulators to the complex.
654 12161 Ensembl ENSG00000153162 n/a UniProt P22004 P20722 RefSeq (mRNA) NM_001718 NM_007556 RefSeq (protein) NP_001709 NP_031582 Location (UCSC) Chr 6: 7.73 – 7.88 Mb n/a PubMed search Wikidata View/Edit Human View/Edit Mouse Bone morphogenetic protein 6 is a protein that in humans is encoded by the BMP6 gene. The protein encoded by this gene is a member of the TGFβ superfamily. Bone ...
10220 14561 Ensembl ENSG00000135414 ENSMUSG00000025352 UniProt O95390 Q9Z1W4 RefSeq (mRNA) NM_005811 NM_010272 RefSeq (protein) NP_005802 NP_034402 Location (UCSC) Chr 12: 55.74 – 55.76 Mb Chr 10: 128.72 – 128.73 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Growth differentiation factor 11 (GDF11), also known as bone morphogenetic protein 11 (BMP-11), is a protein that in ...