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The biosynthesis of monoglycosylceramides requires a direct transfer of the carbohydrate moiety from a sugar-nucleotide, such as uridine 5-diphosphate(UDP)-galactose, or UDP-glucose to the ceramide unit. The glycosyl-transferase catalyzed reaction results in an inversion of the glycosidic bond stereochemistry, changing from α →β.
Ceramides are a family of waxy lipid molecules. A ceramide is composed of sphingosine and a fatty acid joined by an amide bond. Ceramides are found in high concentrations within the cell membrane of eukaryotic cells, since they are component lipids that make up sphingomyelin, one of the major lipids in the lipid bilayer. [1]
7357 22234 Ensembl ENSG00000148154 ENSMUSG00000028381 UniProt Q16739 O88693 RefSeq (mRNA) NM_003358 NM_011673 RefSeq (protein) NP_003349 NP_003349.1 NP_035803 Location (UCSC) Chr 9: 111.9 – 111.94 Mb Chr 4: 59.19 – 59.22 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Ceramide glucosyltransferase is an enzyme that in humans is encoded by the UGCG gene. Glycosphingolipids (GSLs ...
Structure of ceramide, galactosylceramide and glucosylceramide. Galactose or glucose sugars can be attached to a hydroxyl group of ceramide lipids in a different form of O-glycosylation, as it does not occur on proteins. [6] This forms glycosphingolipids, which are important for the localisation of receptors in membranes. [8]
Two dermatologists share the best ceramide moisturizers for every skin type and break down how ceramides work to improve your skin barrier and skin health.
A new Clean Label Project report suggests some protein powders contain heavy metals lead and cadmium. See which ones are safe here, plus what an expert advises.