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The effectiveness of spironolactone in the treatment of both acne and hirsutism appears to be dose-dependent, with higher doses being more effective than lower doses. [ 85 ] [ 96 ] [ 97 ] However, higher doses also have greater side effects, such as menstrual irregularities .
However, spironolactone is metabolized to three active metabolites, which give it prolonged activity (13.8 – 16. 5 hours). Spironolactone has a long half-life and is excreted 47-51% through kidneys. Patients with chronic kidney disease therefore require close monitoring when taking the drug. Spironolactone is also eliminated through feces (35-41%
[61] [62] In addition, other studies have found that 100 mg/day spironolactone is significantly or near-significantly inferior to 500 mg/day flutamide in improving symptoms of acne and hirsutism. [ 63 ] [ 64 ] [ 65 ] One study compared placebo and dosages of spironolactone of 50, 100, 150, and 200 mg/day in the treatment of acne in women and ...
It’s normal for female hormones to fluctuate with each menstrual cycle. ... clinical trials have shown it’s quite effective for hair growth at various doses (0.25 to 2.5 mg daily). Spironolactone.
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An average dose intramuscular injection can vary ... Aldactone: Antiandrogen: Oral: 100–400 mg/day ... 5α-Reductase inhibitors are also used to treat hirsutism ...
For comparison to progesterone, a 200 mg dose of oral progesterone is considered to be approximately equivalent in antimineralocorticoid effect to a 25 to 50 mg dose of spironolactone. [88] Both drospirenone and progesterone are actually weak partial agonists of the MR in the absence of mineralocorticoids. [6] [5] [66]
Hirsutism is excessive body hair on parts of the body where hair is normally absent or minimal. The word is from early 17th century: from Latin hirsutus meaning "hairy". [ 2 ] It usually refers to a male pattern of hair growth in a female that may be a sign of a more serious medical condition, [ 3 ] especially if it develops well after puberty ...