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Bicalutamide is used primarily in the treatment of early and advanced prostate cancer. [1] It is approved at a dosage of 50 mg/day as a combination therapy with a gonadotropin-releasing hormone analogue (GnRH analogue) or orchiectomy (that is, surgical or medical castration) in the treatment of stage D2 metastatic prostate cancer (mPC), [2] [3] and as a monotherapy at a dosage of 150 mg/day ...
Saw palmetto extract is commonly sold as a dietary supplement intended to improve symptoms of benign prostatic hyperplasia (BPH)—also called prostate gland enlargement—which is a common condition among men as they age.
SARMs can be agonists, antagonists, or partial agonists of the AR depending on the tissue, which can enable targeting specific medical conditions while minimizing side effects. [7] Those that have advanced to human trials show stronger effects in bone and muscle tissue and weaker effects in the prostate. [8]
The most commonly reported side effects of dutasteride, although rare, include sexual dysfunction and depression. [8] In the largest available study of 6,729 men with BPH, 9% experienced erectile dysfunction (compared to 5.7% treated with a placebo ), 3.3% experienced decreased sex drive (vs 1.6% of placebo), and 1.9% had enlarged breasts (vs 1 ...
[47] [48] A review from 2020 showed that when abiraterone acetate is used in combination with hormone therapy improves overall survival for men with prostate cancer and also increases the risk of severe and life-threatening side effects that leads to discontinuation of treatment with these drugs. [49]
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