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Dihydralazine is a prescription drug [1] with antihypertensive properties. [2] It functions by combating the effects of adrenaline, and by expanding the blood vessels so as to enable smoother flow of blood by decreasing the pressure. It is generally administered orally, and is available in the form of tablets. [1]
‡ Denotes side effects seen at the above frequency only in clinical trials done in people with soft tissue sarcomas ^ Usually occurs within the first 18 weeks of treatment. 39% of cases develop within the first 9 days of treatment.
Bradycardia; Hypertension (high blood pressure); Allergic reactions (e.g. dyspnoea (shortness of breath), bronchospasm, wheezing, angioneurotic oedema) Anaphylaxis; Changes in appetite
Type A: augmented pharmacological effects, which are dose-dependent and predictable [5]; Type A reactions, which constitute approximately 80% of adverse drug reactions, are usually a consequence of the drug's primary pharmacological effect (e.g., bleeding when using the anticoagulant warfarin) or a low therapeutic index of the drug (e.g., nausea from digoxin), and they are therefore predictable.
Very common (>10% frequency) side effects include headache, tachycardia, and palpitations. [ 13 ] Common (1–10% frequency) side effects include flushing , hypotension , anginal symptoms, aching or swelling joints, muscle aches, positive tests for atrial natriuretic peptide , stomach upset, diarrhea, nausea and vomiting, and swelling (sodium ...
Iproniazid, the first hydrazine MAOI to be discovered.. The hydrazine antidepressants are a group of non-selective, irreversible monoamine oxidase inhibitors (MAOIs) which were discovered and initially marketed in the 1950s and 1960s.
The most prominent side effects are dizziness and sleepiness. [44] Diphenhydramine is a potent anticholinergic agent and potential deliriant in higher doses. This activity is responsible for the side effects of dry mouth and throat, increased heart rate, pupil dilation, urinary retention, constipation, and, at high doses, hallucinations or ...
However, it does act as a high affinity antagonist of the histamine H 1 receptor [24] and is a low to moderate affinity antagonist of the dopamine D 2, serotonin 5-HT 2, and α 1-adrenergic receptors. [3] [23] H 1 receptor antagonism accounts for its antihistamine effects and associated sedative side effects.