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Nevertheless, in 1998, pemphigus vulgaris was the fourth most common cause of death due to a skin disorder. It is thus still deemed "potentially fatal". Pemphigus vulgaris on face. The disease mainly affects middle-aged and older adults between 50 and 60 years old. There has historically been a higher incidence in women. [4]
Pemphigus is further divided in two major subtypes: pemphigus vulgaris (PV) and pemphigus foliaceus (PF). However, several other disorders such as IgA pemphigus, IgE pemphigus, pemphigus herpetiformis, drug-induced pemphigus, Senear Usher syndrome, and endemic pemphigus foliaceus exist, and are recognized by a dermatologist from the appearance ...
It is also associated with pemphigus vulgaris and pemphigus foliaceus. [6] [7] It is useful in differentiating between the diagnosis of pemphigus vulgaris or mucous membrane pemphigoid (where the sign is present) and bullous pemphigoid (where it is absent). The Nikolsky sign is dislodgement of intact superficial epidermis by a shearing force ...
Mucosal pemphigus vulgaris Pemphigus vegetans. Mucocutaneous pemphigus vulgaris [2] Desmoglein 4: Localized autosomal recessive hypotrichosis Autosomal recessive monilethrix: Desmoplakin: Striate palmoplantar keratoderma Carvajal syndrome Skin fragility–wooly hair syndrome Lethal acantholytic epidermolysis bullosa ARVD Paraneoplastic pemphigus
Pemphigus erythematosus (Senear–Usher syndrome) Pemphigus foliaceus; Pemphigus herpetiformis (acantholytic herpetiform dermatitis, herpetiform pemphigus, mixed bullous disease, pemphigus controlled by sulfapyridine) Pemphigoid nodularis; Pemphigus vegetans; Pemphigus vegetans of Hallopeau; Pemphigus vegetans of Neumann; Pemphigus vulgaris ...
This protein, along with Desmoglein-1, has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris. [8] The mucosal dominant form of pemphigus vulgaris only involves antibodies against Desmoglein-3 and causes mucosal erosions, but no skin lesions. [7]
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Pemphigus vulgaris; Cytomegalovirus; Arnault Tzanck did the first cytological examinations in order to diagnose skin diseases. [3] To diagnose pemphigus, he identified acantholytic cells, and to diagnose of herpetic infections he identified multinucleated giant cells and acantholytic cells.