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An anterior chest wall deformity, pectus excavatum, in a person with Marfan syndrome More than 30 signs and symptoms are variably associated with Marfan syndrome. The most prominent of these affect the skeletal, cardiovascular, and ocular systems, but all fibrous connective tissue throughout the body can be affected.
[24] [43] Marfan syndrome, Ehlers–Danlos syndrome, and autosomal dominant polycystic kidney disease are the three most common connective tissue disorders associated with sCSFLs. [24] Roughly 20% of patients with a sCSFL exhibit features of Marfan syndrome, including tall stature, hollowed chest ( pectus excavatum ), joint hypermobility and ...
Dural ectasia can be asymptomatic, in which case no intervention is necessary. However, it is associated with chronic pain in patients with Marfan syndrome, suggesting it is a structural risk factor. [20] There is no medical consensus on how to manage symptomatic (painful) dural ectasia.
Chest pain represents about 5% of presenting problems to the emergency room. [3] In the United States, about 8 million people go to the emergency department with chest pain a year. [1] Of these, about 60% are admitted to either the hospital or an observation unit. [1]
Information card published by the National Heart, Lung, and Blood Institute urging people with symptoms of angina to call the emergency medical services.. Because of the relationship between the duration of myocardial ischemia and the extent of damage to heart muscle, public health services encourage people experiencing possible acute coronary syndrome symptoms or those around them to ...
It is a medical emergency and may require immediate treatment without further investigations (see Treatment section). [15] [16] The most common findings in people with tension pneumothorax are chest pain and respiratory distress, often with an increased heart rate (tachycardia) and rapid breathing in the initial stages
The primary indication for a resuscitative thoracotomy is a patient with penetrating chest trauma who has entered or is about to enter cardiac arrest. [4] Other indications for the use of this procedure include the appearance of blood from a chest tube that returns more than 1500 mL of blood during the first hour of placement, or ≥200 mL of ...
Heritable connective tissue diseases are rare, each disorder estimated at one to ten per 100,000, of which Marfan syndrome is the most common. It is carried by the FBN1 gene on chromosome 15, which encodes the connective protein fibrillin-1, [ 12 ] [ 13 ] inherited as a dominant trait.