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Clostridium tetani is durable due to its endospores. Pictured is the bacterium alone, with a spore being produced, and the spore alone. Tetanus is caused by the tetanus bacterium, Clostridium tetani. [1] The disease is an international health problem, as C. tetani endospores are ubiquitous.
Clostridium tertium bacteremia can cause fever, and directed antibiotic therapy is indicated. [3] C. tertium is commonly (but not universally) resistant to many β-lactam antibiotics such as penicillin and cephalosporin; clindamycin; and metronidazole; but it is susceptible to vancomycin, trimethoprim-sulfamethoxazole, and ciprofloxacin. [3]
TMP/SMX is commonly used due to its ability to achieve high concentrations in urinary tract tissues and urine. This antibiotic combination demonstrates notable efficacy in both the treatment and prophylaxis of recurrent urinary tract infections. [12] Common adverse effects include nausea, vomiting, rash,pruritus, and photosensitivity. [26]
Clostridium tetani is susceptible to a number of antibiotics, including chloramphenicol, clindamycin, erythromycin, penicillin G, and tetracycline. [3] However, the usefulness of treating C. tetani infections with antibiotics remains unclear. [1] Instead, tetanus is often treated with tetanus immune globulin to bind up circulating tetanospasmin ...
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One study found that fluoroquinolone use was associated with a 1.9-fold increase in tendon problems. The risk increased to 3.2 in those over 60 years of age and to 6.2 in those over the age of 60 who were also taking corticosteroids. Among the 46,766 quinolone users in the study, 38 (0.08%) cases of Achilles tendon rupture were identified. [59]