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Deoxycytidine is a deoxyribonucleoside, a component of deoxyribonucleic acid. It is similar to the ribonucleoside cytidine , but with one hydroxyl group removed from the C2' position. Deoxycytidine can be phosphorylated at C5' of the deoxyribose by deoxycytidine kinase , converting it to deoxycytidine monophosphate (dCMP), a DNA precursor.
13178 Ensembl ENSG00000156136 ENSMUSG00000029366 UniProt P27707 P43346 RefSeq (mRNA) NM_000788 NM_007832 RefSeq (protein) NP_000779 NP_031858 Location (UCSC) Chr 4: 70.99 – 71.03 Mb Chr 5: 88.91 – 88.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Deoxycytidine kinase (dCK) is an enzyme which is encoded by the DCK gene in humans. dCK predominantly phosphorylates deoxycytidine ...
Deoxycytidine monophosphate is a molecule of interest in treating genetic disorders such as thymidine kinase 2 (TK2) deficiency.In the case of TK2 deficiency, dCMP in conjunction with deoxythymidine monophosphate (dTMP) to bypass the deficiency in the TK2 enzyme. [2]
[1] [2] [3] Introduced by Gilbert N. Lewis in his 1916 article The Atom and the Molecule, a Lewis structure can be drawn for any covalently bonded molecule, as well as coordination compounds. [ 4 ] Lewis structures extend the concept of the electron dot diagram by adding lines between atoms to represent shared pairs in a chemical bond.
In enzymology, a deoxycytidine deaminase (EC 3.5.4.5) is an enzyme that catalyzes the chemical reaction deoxycytidine + H 2 O ⇌ {\displaystyle \rightleftharpoons } deoxyuridine + NH 3 Thus, the two substrates of this enzyme are deoxycytidine and H 2 O , whereas its two products are deoxyuridine and NH 3 .
Decitabine (i.e., 5-aza-2′-deoxycytidine), sold under the brand name Dacogen among others, acts as a nucleic acid synthesis inhibitor. [4] It is a medication for the treatment of myelodysplastic syndromes, a class of conditions where certain blood cells are dysfunctional, and for acute myeloid leukemia (AML). [5] Chemically, it is a cytidine ...
Deoxycytidine diphosphate is a nucleoside diphosphate. It is related to the common nucleic acid CTP, or cytidine triphosphate, with the -OH group on the 2' carbon on the nucleotide's pentose removed (hence the deoxy- part of the name), and with one fewer phosphoryl group than CTP . 2'-Deoxycytidine diphosphate is abbreviated as dCDP. [1]
Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group.A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (ribose or 2'-deoxyribose) whereas a nucleotide is composed of a nucleobase, a five-carbon sugar, and one or more phosphate groups.