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related to: 2' deoxycytidine 5' monophosphate
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Deoxycytidine monophosphate is a molecule of interest in treating genetic disorders such as thymidine kinase 2 (TK2) deficiency.In the case of TK2 deficiency, dCMP in conjunction with deoxythymidine monophosphate (dTMP) to bypass the deficiency in the TK2 enzyme. [2]
Deoxycytidine is a deoxyribonucleoside, a component of deoxyribonucleic acid. It is similar to the ribonucleoside cytidine , but with one hydroxyl group removed from the C2' position. Deoxycytidine can be phosphorylated at C5' of the deoxyribose by deoxycytidine kinase , converting it to deoxycytidine monophosphate (dCMP), a DNA precursor.
dCMP deaminase (EC 3.5.4.12, deoxycytidylate deaminase, deoxy-CMP-deaminase, deoxycytidylate aminohydrolase, deoxycytidine monophosphate deaminase, deoxycytidine-5'-phosphate deaminase, deoxycytidine-5'-monophosphate aminohydrolase) is an enzyme which converts deoxycytidylic acid to deoxyuridylic acid. [1] [2] [3]
13178 Ensembl ENSG00000156136 ENSMUSG00000029366 UniProt P27707 P43346 RefSeq (mRNA) NM_000788 NM_007832 RefSeq (protein) NP_000779 NP_031858 Location (UCSC) Chr 4: 70.99 – 71.03 Mb Chr 5: 88.91 – 88.93 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Deoxycytidine kinase (dCK) is an enzyme which is encoded by the DCK gene in humans. dCK predominantly phosphorylates deoxycytidine ...
The nucleosides cytidine and deoxycytidine can be salvaged along the uracil pathway by cytidine deaminase, which converts them to uridine and deoxyuridine, respectively. Alternatively, uridine–cytidine kinase can phosphorylate them into cytidine monophosphate (CMP) or deoxycytidine monophosphate (dCMP).
Deoxycytidine diphosphate is a nucleoside diphosphate. It is related to the common nucleic acid CTP, or cytidine triphosphate, with the -OH group on the 2' carbon on the nucleotide's pentose removed (hence the deoxy- part of the name), and with one fewer phosphoryl group than CTP . 2'-Deoxycytidine diphosphate is abbreviated as dCDP. [1]
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66588 Ensembl ENSG00000162368 ENSMUSG00000028719 UniProt P30085 Q9DBP5 RefSeq (mRNA) NM_001136140 NM_016308 NM_001366135 NM_025647 RefSeq (protein) NP_001129612 NP_057392 NP_001353064 NP_079923 Location (UCSC) Chr 1: 47.33 – 47.38 Mb Chr 4: 114.82 – 114.84 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse UMP-CMP kinase is an enzyme that in humans is encoded by the CMPK1 gene ...