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The overall prevalence increases with age, with the largest increase in people over 65 years of age. [3] The prevalence of diabetes in America is estimated to increase to 48.3 million by 2050. [3] Diabetes mellitus occurs throughout the world, but is more common (especially type 2) in the more developed countries.
This is an accepted version of this page This is the latest accepted revision, reviewed on 29 January 2025. Group of endocrine diseases characterized by high blood sugar levels This article is about the common insulin disorder. For the urine hyper-production disorder, see Diabetes insipidus. For other uses, see Diabetes (disambiguation). Medical condition Diabetes Universal blue circle symbol ...
The prevalence of obesity and overweight have risen to epidemic proportions in the United States, where 67% of adults are overweight and, of these, approximately half are obese. [30] [31] The prevalence of hypertension, another cardiometabolic syndrome component, has been increasing for the last decade. In 1994, 24% of U.S. adults had hypertension.
In diabetes mellitus, hyperglycemia is usually caused by low insulin levels (diabetes mellitus type 1) and/or by resistance to insulin at the cellular level (diabetes mellitus type 2), depending on the type and state of the disease. [37]
The presence of metabolic syndrome is associated with a higher prevalence of CVD than found in people with type 2 diabetes or impaired glucose tolerance without the syndrome. [36] Hypoadiponectinemia has been shown to increase insulin resistance [38] and is considered to be a risk factor for developing metabolic syndrome. [39]
Type 2 diabetes is due to insufficient insulin production from beta cells in the setting of insulin resistance. [13] Insulin resistance, which is the inability of cells to respond adequately to normal levels of insulin, occurs primarily within the muscles, liver, and fat tissue. [60] In the liver, insulin normally suppresses glucose release.