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The hypothesis that the immune system identifies the metal ions as foreign bodies and inflames the area around the debris may be incorrect because of the small size of metal ions may prevent them from becoming haptens. [1] Poisoning from metallosis is rare, but cobaltism is an established health concern. The involvement of the immune system in ...
There are reports of cobalt toxicity with hip replacement, particularly metal-on-metal hip replacements, which are no longer in use. [49] [50] Use of metal-on-metal hip replacements from the 1970s was discontinued in the 1980s and 1990s, particularly after the discovery of aseptic lymphocyte-dominant vasculitis-associated lesions (ALVAL).
Medical Device Alert: DePuy ASR TM acetabular cups used in hip resurfacing arthroplasty and total hip replacement, Medicines and Healthcare products Regulatory Agency, MDA/2010/044, 25 May 2010; Medical Device Alert: All metal-on-metal (MoM) hip replacements, Medicines and Healthcare products Regulatory Agency, MDA/2012/008, 28 February 2012
Titanium is considered the most biocompatible metal due to its resistance to corrosion from bodily fluids, bio-inertness, capacity for osseointegration, and high fatigue limit. Titanium's ability to withstand the harsh bodily environment is a result of the protective oxide film that forms naturally in the presence of oxygen.
DePuy faces more than 11,000 plaintiffs nationwide over the ASR XL, which generally allege that the product is prone to degrading prematurely and shedding toxic metal debris, causing pain and necessitating revision surgeries that can be more invasive than the initial total hip replacements.
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Synthetic, self-curing organic or inorganic material used to fill up a cavity or to create a mechanical fixation. Note 1: In situ self-curing can be the source of released reagents that can cause local and/or systemic toxicity as in the case of the monomer released from methacrylics-based bone cement used in orthopedic surgery.
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