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Most patients can achieve good control of their symptoms with first-line treatments. However, some patients may have persistent symptoms despite treatment and may require second-line therapies. [32] Relapse is also common in patients with more severe symptoms. Autoimmune urticaria can be a chronic condition, and managing it may involve ...
Symptoms are thought to be the result of histamine being released by mast cells on the surface of the skin. Despite the lack of antigens, histamine causes the skin to swell in affected areas. If the membrane that surrounds the mast cells is too weak, it will easily and rapidly break down under physical pressure, which then causes an allergic ...
The exact mechanism of the condition is unknown. Some studies have suggested the itching occurs in response to increased fibrinolytic activity in the skin, [5] [6] inappropriate activation of the sympathetic nervous system, [7] increased activity of acetylcholinesterase, [8] [9] or an increase in mast cell degranulation that releases histamine and other chemicals into the body.
Hives, also known as urticaria, is a kind of skin rash with red and/or flesh-colored, raised, itchy bumps. [1] Hives may burn or sting. [2] The patches of rash may appear on different body parts, [2] with variable duration from minutes to days, and do not leave any long-lasting skin change. [2]
Clemastine is a selective histamine H 1 antagonist. It binds to the histamine H 1 receptor, thus blocking the action of endogenous histamine, which leads to temporary relief of the negative symptoms caused by histamine. [11]
Cholinergic urticaria typically presents with a number of small papular hives all over the body, that involve cutaneous inflammation (wheals) and severe nerve pain, which usually develops in response to exercise, bathing, staying in a heated environment, spicy foods, or emotional stress.
Treating allergy symptoms with over-the-counter medication, saline spray, and, if warranted, allergy medication or injections from your doctor, may also help reduce GI symptoms as a result.
The other symptoms caused by allergic contact dermatitis may be eased with cool compresses to stop the itching. It is vital for treatment success that the trigger be identified and avoided. The discomfort caused by the symptoms may be relieved by wearing smooth-textured cotton clothing to avoid frictional skin irritation or by avoiding soaps ...
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