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Domperidone, sold under the brand name Motilium among others, is a dopamine antagonist medication which is used to treat nausea and vomiting and certain gastrointestinal problems like gastroparesis (delayed gastric emptying).
Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS) and are implicated in many neurological processes, including motivational and incentive salience, cognition, memory, learning, and fine motor control, as well as modulation of neuroendocrine signaling.
Deudomperidone (developmental code name CIN-102; also known as deuterated domperidone) is a dopamine antagonist medication which is under development in the United States for the treatment of gastroparesis. [1] [2] [3] It acts as a selective dopamine D 2 and D 3 receptor antagonist and has peripheral selectivity.
Dopamine receptor D 2, also known as D 2 R, is a protein that, in humans, is encoded by the DRD2 gene.After work from Paul Greengard's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups, including those of Solomon H. Snyder and Philip Seeman used a radiolabeled antipsychotic drug to identify what is now known as the dopamine D 2 receptor. [5]
In 2001, the FDA changed the labeling requirements for droperidol injection to include a Black Box Warning, citing concerns of QT prolongation and torsades de pointes.The evidence for this is disputed, with 9 reported cases of torsades in 30 years and all of those having received doses in excess of 5 mg. [9] QT prolongation is a dose-related effect, [10] and it appears that droperidol is not a ...
Prochlorperazine is a medication used to treat nausea, vomiting, and other conditions.
Galactogogues such as the peripherally selective D 2 receptor antagonist and prolactin releaser domperidone can be used to induce lactation in transgender women who wish to breastfeed. [273] [274] [65] An extended period of combined estrogen and progestogen therapy is necessary to mature the lobuloalveolar tissue of the breasts before this can ...
As so often in Wikipedia, this is US-biased. Domperidone (branded as Motilium) is widely available in in the UK without prescription from pharmacies, but this is not made clear. EnglishBriarRose 04:22, 5 January 2013 (UTC) A discussion of how it is used in the UK in regards brain tumour treatment would be useful.