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Research shows that taking 5 milligrams (mg) of finasteride a day for benign prostatic hyperplasia (BPH) — an enlarged prostate — can lead to a 15 to 25 percent increase in testosterone levels.
Originally, finasteride was FDA-approved as medication for benign prostatic hyperplasia, or BPH — a form of non-cancerous prostate enlargement — under the brand name Proscar.
Finasteride is a hair loss treatment approved by the FDA (U.S. Food and Drug Administration) to treat androgenic alopecia in men (male pattern hair loss) and benign prostatic hyperplasia (BHP, or ...
In the prostate, this reduces prostate volume, which improves BPH and reduces the risk of prostate cancer. Finasteride reduces prostate volume by 20 to 30% in men with benign prostatic hyperplasia. [75] Inhibition of 5α-reductase also reduces epididymal weight, and decreases motility and normal morphology of spermatozoa in the epididymis. [76]
Dutasteride (brand name Avodart) inhibits all three 5α-reductase isoenzymes and can decrease DHT levels by 95%. [9] [10] It can also reduce DHT levels in the prostate by 97 to 99% in men with prostate cancer. [11] [12] Epristeride (brand names Aipuliete, Chuanliu) is marketed in China for the treatment of benign prostatic hyperplasia.
Lowering androgen levels or stopping them from getting into prostate cancer cells often makes prostate cancer shrink or grow more slowly for a time. However, this treatment needs to be combined with radiation therapy (RT) [ 8 ] because ADT itself does not eradicate the cancer ; it just decreases its aggressiveness.