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This story was reviewed by Mike Bohl, MD. In the ‘80s, researchers set out to test a medication called sildenafil citrate for treating high blood pressure and angina (chest pain) from heart disease.
When that happens, blood pressure in the lungs increases, and the heart has to work harder to get blood through those tiny arteries — a process that can eventually tire out the lungs ...
When you have high blood pressure, your heart and blood vessels have to work harder to make blood flow through your body. This is pretty much the opposite of what sildenafil does — as a reminder ...
Sildenafil, sold under the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. [4] [8] It is also sometimes used off-label for the treatment of certain symptoms in secondary Raynaud's phenomenon. [9]
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Heart attack. Stroke. Dizziness. Sudden low blood pressure. You could also face serious risks from drug interactions. Taking this medication with other medications and products can be dangerous, ...
Chronotropic effects (from chrono-, meaning time, and tropos, "a turn") are those that change the heart rate. Chronotropic drugs may change the heart rate and rhythm by affecting the electrical conduction system of the heart and the nerves that influence it , such as by changing the rhythm produced by the sinoatrial node .
Sildenafil and other PDE-5 inhibitor medications can interact with other drugs, including several common medications used to treat chest pain, high blood pressure (sildenafil can cause low blood ...