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The TM-score indicates the similarity between two structures by a score between (,], where 1 indicates a perfect match between two structures (thus the higher the better). [1] Generally scores below 0.20 corresponds to randomly chosen unrelated proteins whereas structures with a score higher than 0.5 assume roughly the same fold. [ 2 ]
TM-align TM-score based protein structure alignment: Cα: Pair: nil: server and download: Y. Zhang & J. Skolnick: 2005 mTM-align Multiple protein structure alignment based on TM-align Cα Multi No server and download: R. Dong, Z. Peng, Y. Zhang & J. Yang 2018 VAST Vector Alignment Search Tool: SSE: Pair: nil: server: S. Bryant: 1996 PrISM
Each of these scenarios is assigned a score and the sum of the scores of all the pairings is the score of the whole alignment candidate. Different systems exist for assigning scores; some have been outlined in the Scoring systems section below. For now, the system used by Needleman and Wunsch [1] [failed verification] will be used:
Max in TM-score equation. It would be helpful to explain what this max is taken over. Aviad.rubinstein 21:25, 30 July 2021 (UTC) This page was ...
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The mutual information (MI) of the random variables X and Y is the expected value of the PMI (over all possible outcomes). The measure is symmetric ( (;) = (;)). It can take positive or negative values, but is zero if X and Y are independent. Note that even though PMI may be negative or positive, its expected outcome over all joint ...
Some have alleged that departures in normality in the process output significantly reduce the effectiveness of the charts to the point where it may require control limits to be set based on percentiles of the empirically-determined distribution of the process output [2]: 237 although this assertion has been consistently refuted. See Footnote 6.
In statistical quality control, the CUSUM (or cumulative sum control chart) is a sequential analysis technique developed by E. S. Page of the University of Cambridge. It is typically used for monitoring change detection . [ 1 ]