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Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval.
While usually due to aspirin, other possible causes include oil of wintergreen and bismuth subsalicylate. [2] Excess doses can be either on purpose or accidental. [1] Small amounts of oil of wintergreen can be toxic. [2] Diagnosis is generally based on repeated blood tests measuring aspirin levels and blood gases. [1]
[149] [150] Naproxen has been shown to be as effective as aspirin and less toxic, but due to the limited clinical experience, naproxen is recommended only as a second-line treatment. [ 149 ] [ 151 ] Along with rheumatic fever, Kawasaki disease remains one of the few indications for aspirin use in children [ 152 ] in spite of a lack of high ...
The serious symptoms of Reye syndrome appear to result from damage to cellular mitochondria, [14] at least in the liver, and there are a number of ways that aspirin could cause or exacerbate mitochondrial damage. A potential increased risk of developing Reye syndrome is one of the main reasons that aspirin has not been recommended for use in ...
Chances are, you adhered to many of these falsehoods without realizing the damage they may have caused. Fortunately, sites like Reddit provide medical professionals with a platform to debunk some ...
Due to the pH of the small intestine, most of the bile acids are ionized and mostly occur as their sodium salts which are then called “primary conjugated bile salts.” In the lower small intestine and colon , bacteria dehydroxylate some of the primary bile salts to form secondary conjugated bile salts (which are still water-soluble).