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Digibind is manufactured by GlaxoSmithkline, SpA, Parma Italy under US License No. 129. It’s distributed by GSK, Research Triangle park, NC 27709. A patent to use digoxin immunoglobulins C07k16/44 as a regulator of the preeclamptic/eclamptic patient's sodium/potassium ATPase activity was approved in 2003 to Charles David Adair under ...
In toxicity, the usual supportive measures are provided. If arrhythmias prove troublesome, or malignant hyperkalaemia occurs (inexorably rising potassium level due to paralysis of the cell membrane-bound, ATPase-dependent Na/K pumps), the specific antidote is antidigoxin (antibody fragments against digoxin, trade names Digibind and Digifab). [7]
The mechanism of action for drugs such as Digibind and Digifab, used when adverse events occur with the use of digoxin, is that the FAB regions on the antibodies created against digoxin expedite the excretion of the drug into urine. Therefore, the amount of digoxin in the body decreases quickly as it gets excreted rapidly.
However, polyclonal antibodies in mice can be collected from ascites fluid using any one of a number of ascites producing methodologies. When using rabbits, young adult animals (2.5–3.0 kg or 5.5–6.5 lb) should be used for primary immunization because of the vigorous antibody response.
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Physiological antagonism describes the behavior of a substance that produces effects counteracting those of another substance (a result similar to that produced by an antagonist blocking the action of an agonist at the same receptor) using a mechanism that does not involve binding to the same receptor.
The papain-digested antibody is unable to promote agglutination, precipitation, opsonization, and lysis, however, the Fab fragment is still able to bind to and neutralize appropriate antigens, most commonly seen in the use of sheep anti-Crotalid toxin antibody preparations, known as CroFab and in Digibind, a similar sheep antiserum fragment ...
Use the two letter country code with a wikilink to the country (eg [ CA]) Use comma separated list for multiple countries (eg [ CA, US] Problem is that I can't find an easy and nice way to put square brackets around a wikilink (without those ugly spaces). To me, square brackets are preferable, but maybe it would be best to go with curly braces.