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Phosphoric acid (orthophosphoric acid, monophosphoric acid or phosphoric(V) acid) is a colorless, odorless phosphorus-containing solid, and inorganic compound with the chemical formula H 3 P O 4. It is commonly encountered as an 85% aqueous solution , which is a colourless, odourless, and non- volatile syrupy liquid.
The "backbone" of a polyphosphoric acid molecule is a chain of alternating P and O atoms. Each extra orthophosphoric unit that is condensed adds 1 extra H atom, 1 extra P atom, and 3 extra O atoms. The general formula of a polyphosphoric acid is H n+2 P n O 3n+1 or HO[−P(O)(OH)−O−] n H.
In chemistry, a phosphate is an anion, salt, functional group or ester derived from a phosphoric acid. It most commonly means orthophosphate, a derivative of orthophosphoric acid, a.k.a. phosphoric acid H 3 PO 4. The phosphate or orthophosphate ion [PO 4] 3− is derived from phosphoric acid by the removal of three protons H +.
Etoricoxib, sold under the brand name Arcoxia, is a selective COX-2 inhibitor developed and commercialized by Merck.It is approved in 63 countries worldwide as of 2007, except the United States where the Food and Drug Administration sent a Non Approvable Letter to Merck and required them to provide additional data.
POCl 3 reacts with water to give hydrogen chloride and phosphoric acid: O=PCl 3 + 3 H 2 O → O=P(OH) 3 + 3 HCl. Intermediates in the conversion have been isolated, including pyrophosphoryl chloride, O(−P(=O)Cl 2) 2. [9] Upon treatment with excess alcohols and phenols, POCl 3 gives phosphate esters: O=PCl 3 + 3 ROH → O=P(OR) 3 + 3 HCl
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The therapeutic recommended dosages were 12.5, 25, and 50 mg with an approximate bioavailability of 93%. [12] [13] [14] Rofecoxib crossed the placenta and blood–brain barrier, [12] [13] [15] and took 1–3 hours to reach peak plasma concentration with an effective half-life (based on steady-state levels) around 17 hours.
For example, dehydration of orthoperiodic acid gives metaperiodic acid. Such naming conventions are now obsolete; however, various traditional names containing these prefixes have been retained in IUPAC nomenclature, namely: orthosilicic acid, Si(OH) 4; orthotelluric acid, Te(OH) 6; orthophosphoric acid, PO(OH) 3; orthoboric acid, B(OH) 3