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The most common presentation of cerebrovascular disease is an ischemic stroke or mini-stroke and sometimes a hemorrhagic stroke. [2] Hypertension (high blood pressure) is the most important contributing risk factor for stroke and cerebrovascular diseases as it can change the structure of blood vessels and result in atherosclerosis. [5]
The cells of the neurovascular unit also make up the blood–brain barrier (BBB), which plays an important role in maintaining the microenvironment of the brain. [11] In addition to regulating the exit and entrance of blood, the blood–brain barrier also filters toxins that may cause inflammation, injury, and disease. [12]
Articles relating to cerebrovascular diseases, a variety of medical conditions that affect the blood vessels of the brain and the cerebral circulation
Macrovascular disease is a disease of any large (macro) blood vessels in the body. It is a disease of the large blood vessels, including the coronary arteries, the aorta, and the sizable arteries in the brain and in the limbs.
Likewise, sepsis and trauma are examples of foreign insults, [2] and encephalitis, multiple sclerosis, and brain tumors are examples of insults to the brain. [3] Clinicians may use the term cerebrovascular insult (CVI) as a synonym for a stroke. [4] [5] Insults may be categorized as either genetic or environmental. [6]
Cerebral circulation is the movement of blood through a network of cerebral arteries and veins supplying the brain.The rate of cerebral blood flow in an adult human is typically 750 milliliters per minute, or about 15% of cardiac output.
For example, cerebrovascular disease involves brain injury due to problems with the blood vessels (cardiovascular system) supplying the brain; autoimmune disorders involve damage caused by the body's own immune system; lysosomal storage diseases such as Niemann–Pick disease can lead to neurological deterioration.
This definition was supposed to reflect the reversibility of tissue damage and was devised for the purpose, with the time frame of 24 hours being chosen arbitrarily. The 24-hour limit divides stroke from transient ischemic attack, which is a related syndrome of stroke symptoms that resolve completely within 24 hours. [2]