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The conventional drug delivery system is the absorption of the drug across a biological membrane, whereas the targeted release system releases the drug in a dosage form. The advantages to the targeted release system is the reduction in the frequency of the dosages taken by the patient, having a more uniform effect of the drug, reduction of drug ...
For example, Makhmalzadeh et al. proposed an ultrasound-triggered drug delivery method involving the use of thermo-responsive hydrogels loaded with silibinin, a cancer drug for treating melanoma. [ 16 ] [ 41 ] At low temperatures, these thermo-responsive hydrogels exist in liquid form but following ultrasonication, they transition into a gel state.
Interest in targeted drug delivery has grown drastically due to its potential implications in the treatment of cancers and other chronic diseases. [23] [24] [25] In order to achieve efficient targeted delivery, the designed system must avoid the host's defense mechanisms and circulate to its intended site of action. [26]
Conventional drug delivery is limited by the inability to control dosing, target specific sites, and achieve targeted permeability. Traditional methods of delivering therapeutics to the body experience challenges in achieving and maintaining maximum therapeutic effect while avoiding the effects of drug toxicity.
These drug delivery systems have been created to react to the pH environment of diseased or cancerous tissues, triggering structural and chemical changes within the drug delivery system. [3] This form of targeted drug delivery is to localize drug delivery, prolongs the drug's effect, and protect the drug from being broken down or eliminated by ...
Though immunoliposomes serve as a possible advancement, there are other therapies similar to it that trail on the role of targeted drug delivery systems. [19] One example of such therapy is Immune Polymeric nanoparticles, which are similar to liposomes but consist of small particles composed of biodegradable polymers. [19] These nanoparticles ...
Enhanced drug uptake using acoustic targeted drug delivery. Drug Delivery. Delivering chemotherapy to brain cancer cells and various drugs to other tissues is called acoustic targeted drug delivery. [5] These procedures generally use high frequency ultrasound (1–10 MHz) and a range of intensities (0–20 W/cm 2). The acoustic energy is ...
Overall, microdroplet-based drug delivery systems show great promise for revolutionizing medicine with significant potential for targeted drug delivery. Limitations Nevertheless, it is essential to note some common challenges associated with microdroplet-based drug delivery systems, including their biocompatibility, toxicity, and scalability. [2]