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Mephedrone, also known as 4-methylmethcathinone, 4-MMC, and 4-methylephedrone, is a synthetic stimulant drug belonging to the amphetamine and cathinone classes. It is commonly referred to by slang names such as drone, [5] M-CAT, [6] white magic, [7] meow meow, and bubble. [8]
IC 50 (nM) Mephedrone 769 ± 106 319 ± 40 600 ± 99 4-CMC 1014 ± 78 559 ± 57 542 ± 38 Legality. 4-CMC is an Anlage I controlled drug in Germany.
Methcathinone / ˌ m ɛ θ ˈ k æ θ ɪ ˌ n oʊ n / (α-methyl amino-propiophenone or ephedrone) (sometimes called "cat" or "jeff" or "catnip" or "M-Kat" or "kat" or "intash") is a monoamine alkaloid and psychoactive stimulant, a substituted cathinone.
4-Methylpentedrone (also known as 4-MPD and 4-Methyl-α-methylamino-valerophenone), is a stimulant drug of the cathinone class that has been sold online as a designer drug.It is a higher homolog of 4-methylmethcathinone (mephedrone) and 4-methylbuphedrone (4-MeMABP), and the p-methyl derivative of pentedrone.
3-Methylmethcathinone (3-MMC), also known as metaphedrone, [4] is a designer drug from the substituted cathinone family. 3-MMC is a monoamine transporter substrate (a substance acted upon by monoamine transporters) that potently releases and inhibits the reuptake of dopamine and norepinephrine, as well as displaying moderate serotonin releasing activity.
[5] [6] Conversely, mephedrone shows no dopaminergic neurotoxicity at all in mice. [ 5 ] [ 6 ] It was theorized that 4-methyl and β-keto substitutions on amphetamines may result in loss of activity at the vesicular monoamine transporter 2 (VMAT2), loss of elevations of cytosolic dopamine concentrations, and consequent loss of dopaminergic ...
The pharmacology for ethcathinone appeared alongside other psychostimulants in a paper by Rothman and Baumann in 2006. [6] The predominant two modes of action for ethcathinone is as a moderately active releaser of noradrenaline (EC 50 = 99.3 nM); [6] however it is only a relatively weak inhibitor of dopamine reuptake (K i = 1,014 nM).
4-MC is a serotonin–norepinephrine–dopamine releasing agent (SNDRA) similarly to mephedrone. [ 5 ] [ 6 ] [ 7 ] It displays a 2.4-fold selectivity to promote monoamine release via DAT over SERT as opposed to 309-fold selectivity for cathinone . [ 6 ]