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Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. [9] Haloperidol is used in the treatment of schizophrenia , tics in Tourette syndrome , mania in bipolar disorder , delirium , agitation, acute psychosis , and hallucinations from alcohol withdrawal .
Haloperidol decanoate is provided in the form of 50 or 100 mg/mL oil solution of sesame oil and benzyl alcohol in ampoules or pre-filled syringes. [6] [7] [9] Its elimination half-life after multiple doses is 21 days. [10] [11] The medication is marketed in many countries throughout the world. [3] [12
Typical antipsychotics can be used to treat, e.g., schizophrenia or severe agitation. [5] Haloperidol, due to the availability of a rapid-acting injectable formulation and decades of use, remains the most commonly used antipsychotic for treating severe agitation in the emergency department setting. [5]
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Atypical and typical antipsychotics have been shown to be helpful in the early stages of treatment, especially olanzapine over haloperidol. [8] The benzodiazepines temazepam and triazolam at 30 mg and 0.5 mg (prescribed independently from olanzapine [ 39 ] [ 40 ] and haloperidol [ 41 ] [ 42 ] ), are highly effective if aggression, agitation, or ...
According to a 2008 study, taking an SSRI with a benzodiazepine can help regulate anxiety quickly. It can also help patients deal with the agitation that can occur when you first start taking an SSRI.
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Dopamine receptor flow chart. Dopamine receptors are all G protein–coupled receptors, and are divided into two classes based on which G-protein they are coupled to. [1] The D 1-like class of dopamine receptors is coupled to Gα s/olf and stimulates adenylate cyclase production, whereas the D 2-like class is coupled to Gα i/o and thus inhibits adenylate cyclase production.