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Diltiazem, sold under the brand name Cardizem among others, is a nondihydropyridine calcium channel blocker medication used to treat high blood pressure, angina, and certain heart arrhythmias. [9] It may also be used in hyperthyroidism if beta blockers cannot be used. [ 9 ]
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1,3-thiazepine 1,4-thiazepine Diltiazem. 1,4-thiazepine is the seven membered ring in the middle. Thiazepines are substituted thiepins, with a nitrogen replacing a carbon in the seven-membered heterocyclic compound. [1] Depending on the location of the nitrogen, one distinguishes 1,3-thiazepine and 1,4-thiazepine. [1]
154. diltiazem 155. dinoprostone 156. diphenoxylate, its salts 157. dipivefrin hydrochloride 158. di-sodium pamidronate 159. disopyramide 160. docetaxel 161. domperidone 162. donepezil hydrochloride 163. dopamine hydrochloride 164. dothiepin hydrochloride 165. doxapram hydrochloride 166. doxazosin mesylate 167. doxepin hydrochloride 168.
Calcium channel blockers such as verapamil and diltiazem have a longer half-life compared to adenosine. Although these blockers are safe when administered slowly, adenosine is considered safer and particularly useful in cases where an electrocardiogram does not provide clear information.
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Valsartan, sold under the brand name Diovan among others, is a medication used to treat high blood pressure, heart failure, and diabetic kidney disease. [8] It belongs to a class of medications referred to as angiotensin II receptor blockers (ARBs).
Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval.