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The drug is used to treat acute and chronic pain. It has shown effectiveness in the treatment of fibromyalgia, though it is not specifically approved for this purpose. The drug is also under investigation as an antidepressant and for the treatment of neuropathic pain. It is related in chemical structure to venlafaxine.
During its development for fibromyalgia, milnacipran was evaluated utilizing a composite responder approach.To be considered as a responder for the composite ‘treatment of fibromyalgia’ endpoint, each patient had to show concurrent and clinically meaningful improvements in pain, physical function, and global impression of disease status.
The use of medication in the treatment of fibromyalgia is debated, [18] [19] although antidepressants can improve quality of life. [20] Other medications commonly considered helpful in managing fibromyalgia include serotonin–norepinephrine reuptake inhibitors, nonsteroidal anti-inflammatory drugs, and muscle relaxants. [21]
Antidepressants are a class of medications used very commonly to treat depression. In fact, nearly 13 percent of people 12 and over in the U.S. used antidepressants in 2017, according to the ...
Widely misunderstood but fairly common, fibromyalgia is characterized by widespread pain in your bones, muscles, or ligaments—which affects about 10 million Americans, according to the National ...
A 2014 Cochrane review concluded that duloxetine is beneficial in the treatment of diabetic neuropathy and fibromyalgia but that more comparative studies with other medicines are needed. [22] The French medical journal Prescrire concluded that duloxetine is no better than other available agents and has a greater risk of side effects. [ 23 ]