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  2. Primary transcript - Wikipedia

    en.wikipedia.org/wiki/Primary_transcript

    RNA polymerase is often incapable of synthesizing a primary transcript if the targeted gene's promoter region contains specific methylated cytosines— residues that hinder binding of transcription-activating factors and recruit other enzymes to stabilize a tightly bound nucleosome structure, excluding access to RNA polymerase and preventing ...

  3. Upstream and downstream (DNA) - Wikipedia

    en.wikipedia.org/wiki/Upstream_and_downstream_(DNA)

    Each strand of DNA or RNA has a 5' end and a 3' end, so named for the carbon position on the deoxyribose (or ribose) ring. By convention, upstream and downstream relate to the 5' to 3' direction respectively in which RNA transcription takes place. [1] Upstream is toward the 5' end of the RNA molecule, and downstream is toward the 3

  4. Open reading frame - Wikipedia

    en.wikipedia.org/wiki/Open_reading_frame

    That start codon (not necessarily the first) indicates where translation may start. The transcription termination site is located after the ORF, beyond the translation stop codon. If transcription were to cease before the stop codon, an incomplete protein would be made during translation. [3]

  5. Messenger RNA - Wikipedia

    en.wikipedia.org/wiki/Messenger_RNA

    A 5' cap (also termed an RNA cap, an RNA 7-methylguanosine cap, or an RNA m 7 G cap) is a modified guanine nucleotide that has been added to the "front" or 5' end of a eukaryotic messenger RNA shortly after the start of transcription. The 5' cap consists of a terminal 7-methylguanosine residue that is linked through a 5'-5'-triphosphate bond to ...

  6. Central dogma of molecular biology - Wikipedia

    en.wikipedia.org/wiki/Central_dogma_of_molecular...

    A second version of the central dogma is popular but incorrect. This is the simplistic DNA → RNA → protein pathway published by James Watson in the first edition of The Molecular Biology of the Gene (1965). Watson's version differs from Crick's because Watson describes a two-step (DNA → RNA and RNA → protein) process as the central ...

  7. Transcription (biology) - Wikipedia

    en.wikipedia.org/wiki/Transcription_(biology)

    RNA polymerase, assisted by one or more general transcription factors, then selects a transcription start site in the transcription bubble, binds to an initiating NTP and an extending NTP (or a short RNA primer and an extending NTP) complementary to the transcription start site sequence, and catalyzes bond formation to yield an initial RNA product.

  8. Scientists recover RNA from an extinct species for the first time

    www.aol.com/scientists-recover-rna-extinct...

    In 2019, a team sequenced RNA from the skin of a 14,300-year-old wolf that was preserved in permafrost, but the latest research is the first time RNA has been retrieved from an animal that is now ...

  9. Eukaryotic transcription - Wikipedia

    en.wikipedia.org/wiki/Eukaryotic_transcription

    Eukaryotic Transcription. Eukaryotic transcription is the elaborate process that eukaryotic cells use to copy genetic information stored in DNA into units of transportable complementary RNA replica. [1] Gene transcription occurs in both eukaryotic and prokaryotic cells. Unlike prokaryotic RNA polymerase that initiates the transcription of all ...