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Endochondral ossification is the process by which most vertebrate axial skeletons form into hardened bones from cartilage. This process begins with a cartilage anlage where chondrocyte cells will congregate and start their maturation process. Once the chondrocytes have fully matured at the desired rate, the cartilage tissue will harden into ...
A spotted gar larva at 22 days stained for cartilage (blue) and bone (red). Chondrogenesis is the biological process through which cartilage tissue is formed and developed. . This intricate and tightly regulated cellular differentiation pathway plays a crucial role in skeletal development, as cartilage serves as a fundamental component of the embryonic skele
Diagram showing stages of endochondral ossification. Endochondral ossification is the formation of long bones and other bones. This requires a hyaline cartilage precursor. There are two centers of ossification for endochondral ossification. The primary center. In long bones, bone tissue first appears in the diaphysis (middle of shaft).
The initiation of endochondral ossification starts by proliferation and condensation of mesenchymal cells in the area where the bone will eventually be formed. Subsequently, these mesenchymal progenitor cells differentiate into chondroblasts, which actively synthesize cartilage matrix components.
The epiphyseal plate, epiphysial plate, physis, or growth plate is a hyaline cartilage plate in the metaphysis at each end of a long bone.It is the part of a long bone where new bone growth takes place; that is, the whole bone is alive, with maintenance remodeling throughout its existing bone tissue, but the growth plate is the place where the long bone grows longer (adds length).
The cartilage cells or chondrocytes are contained in cavities in the matrix, called cartilage lacunae; around these, the matrix is arranged in concentric lines as if it had been formed in successive portions around the cartilage cells. This constitutes the so-called capsule of the space.
Chondroblasts, or perichondrial cells, is the name given to mesenchymal progenitor cells in situ which, from endochondral ossification, will form chondrocytes in the growing cartilage matrix. Another name for them is subchondral cortico-spongious progenitors. [1] They have euchromatic nuclei and stain by basic dyes.
In a long bone it is a thin disc of hyaline cartilage that is positioned transversely between the epiphysis and metaphysis. In the long bones of humans, the epiphyseal plate disappears by twenty years of age. physis, "the growth part" metaphysis: The region of a long bone lying between the epiphysis and diaphysis.