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Cryoprecipitate, also called cryo for short, or Cryoprecipitate Antihemophilic factor (AHF), is a frozen blood product prepared from blood plasma. [1] To create cryoprecipitate, Plasma is slowly thawed to 1–6 °C. A cold-insoluble precipitate is formed, which is collected by centrifugation, resuspended in a small amount of residual plasma ...
The Cohn process, developed by Edwin J. Cohn, is a series of purification steps with the purpose of extracting albumin from blood plasma.The process is based on the differential solubility of albumin and other plasma proteins based on pH, ethanol concentration, temperature, ionic strength, and protein concentration.
The term cryosupernatant (also called cryo-poor plasma, cryoprecipitate depleted, cryoprecipitate reduced plasma) refers to plasma from which the cryoprecipitate has been removed. It is used to treat thrombocytopenic purpura .
Fresh frozen plasma is made up of a complex mixture of water, proteins, carbohydrates, fats, and vitamins. [1] When frozen it lasts about a year. [1] Plasma first came into medical use during the Second World War. [1] It is on the World Health Organization's List of Essential Medicines. [7] In the United Kingdom it costs about £30 per unit. [8]
A blood substitute (also called artificial blood or blood surrogate) is a substance used to mimic and fulfill some functions of biological blood.It aims to provide an alternative to blood transfusion, which is transferring blood or blood-based products from one person into another.
The high-glycerol method uses 40% weight/volume glycerol, a slow freezing rate (1–3 °C per minute) and allows storage of the frozen red blood cells in common mechanical −60–80 °C freezers. The low-glycerol method is based on 20% weight/volume glycerol and demands plunge freezing in (−150 °C) liquid nitrogen.
A blood product is any therapeutic substance prepared from human blood. [1] This includes whole blood; blood components; and plasma derivatives.Blood components include: red blood cell concentrates or suspensions; platelets produced from whole blood or via apheresis; Granulocyte, plasma; and cryoprecipitate.
Plasminogen activator inhibitor-1 is a serine protease, synthesized by endothelial cells, that specifically inhibits tissue plasminogen activator (tPA) and urokinase (uPA). Tissue plasminogen activator and urokinase are the activators of plasminogen and result in the breakdown of blood clots ( fibrinolysis ).