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  2. Adenosine receptor - Wikipedia

    en.wikipedia.org/wiki/Adenosine_receptor

    Caffeine keeps you awake by blocking adenosine receptors. Each type of adenosine receptor has different functions, although with some overlap. [3] For instance, both A 1 receptors and A 2A play roles in the heart, regulating myocardial oxygen consumption and coronary blood flow, while the A 2A receptor also has broader anti-inflammatory effects throughout the body. [4]

  3. Adenosine A2A receptor - Wikipedia

    en.wikipedia.org/wiki/Adenosine_A2A_receptor

    The adenosine A2A receptor has also been shown to play a regulatory role in the adaptive immune system. In this role, it functions similarly to programmed cell death-1 (PD-1) and cytotoxic t-lymphocyte associated protein-4 ( CTLA-4 ) receptors, namely to suppress immunologic response and prevent associated tissue damage.

  4. Adenosine A1 receptor - Wikipedia

    en.wikipedia.org/wiki/Adenosine_A1_receptor

    However, in altered cardiac function, such as hypoperfusion caused by hypotension, heart attack or cardiac arrest caused by nonperfusing bradycardias, adenosine has a negative effect on physiological functioning by preventing necessary compensatory increases in heart rate and blood pressure that attempt to maintain cerebral perfusion.

  5. Purinergic signalling - Wikipedia

    en.wikipedia.org/wiki/Purinergic_signalling

    In neutrophils, tissue adenosine can either activate or inhibit various neutrophil functions, depending on the inflammatory microenvironment, the expression of adenosine receptors on the neutrophil, and the affinity of these receptors for adenosine. Micromolar concentrations of adenosine activate A2A and A2B receptors.

  6. Adenosine - Wikipedia

    en.wikipedia.org/wiki/Adenosine

    The A 1 receptors couple to G i/o and decrease cAMP levels, while the A 2 adenosine receptors couple to G s, which stimulates adenylate cyclase activity. In addition, A 1 receptors couple to G o , which has been reported to mediate adenosine inhibition of Ca 2+ conductance, whereas A 2B and A 3 receptors also couple to G q and stimulate ...

  7. Alpha-2 adrenergic receptor - Wikipedia

    en.wikipedia.org/wiki/Alpha-2_adrenergic_receptor

    The α 2-adrenergic receptor binds both norepinephrine released by sympathetic postganglionic fibers and epinephrine (adrenaline) released by the adrenal medulla, binding norepinephrine with slightly higher affinity. [4] It has several general functions in common with the α 1-adrenergic receptor, but also has specific effects of its own.

  8. Cooking oil linked to colon cancer in early study, tied to ...

    www.aol.com/cooking-oil-linked-colon-cancer...

    Seed oils — plant-based cooking oils often used in processed, packaged foods — have been linked to an increased risk of colon cancer, according to a new study published in the medical journal Gut.

  9. Adenosine A2A receptor antagonist - Wikipedia

    en.wikipedia.org/wiki/Adenosine_A2A_Receptor...

    Adenosine A 2A receptor locations in the body could help us to understand the possible therapeutic applications in the future. They can be found in the lungs, white blood cells, sympathetic nervous system, striatum, tuberculum olfactorium, coronary, lymphatic, brain and other blood vessels, platelets and kidneys.