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“Alzheimer’s disease has a long pre-symptomatic period; Alzheimer’s-related changes take place in the brain 10, 15, even 20 years before the onset of memory and thinking symptoms.
The first symptoms are often mistakenly attributed to aging or stress. [34] Detailed neuropsychological testing can reveal mild cognitive difficulties up to eight years before a person fulfills the clinical criteria for diagnosis of Alzheimer's disease. [35] These early symptoms can affect the most complex activities of daily living. [36]
The signs and symptoms of dementia are termed as the neuropsychiatric symptoms—also known as the behavioral and psychological symptoms—of dementia. [21] [22] The behavioral symptoms can include agitation, restlessness, inappropriate behavior, sexual disinhibition, and verbal or physical aggression. [23]
Signs and symptoms are classified into three groups based on the affected functions of the frontal and temporal lobes: [8] These are behavioural variant frontotemporal dementia, semantic dementia, and progressive nonfluent aphasia. An overlap between symptoms can occur as the disease progresses and spreads through the brain regions. [14]
The charity’s poll of 1,019 dementia sufferers and their carers found that confusing dementia symptoms with getting old (42%) was the number one reason it took people so long to get a diagnosis.
[21] [22] These early signs and symptoms can appear 15 years or more before dementia develops. [21] The earliest symptoms are constipation and dizziness from autonomic dysfunction, hyposmia (reduced ability to smell), RBD, anxiety, and depression. [22] [23] RBD may appear years or decades before other symptoms. [7] Memory loss is not always an ...
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