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It contains both ascending and descending fibers. The mesolimbic pathway, which is a collection of dopaminergic neurons that projects from the ventral tegmental area to the nucleus accumbens, is a component pathway of the MFB. [2] The MFB is one of the two major pathways connecting the limbic forebrain, midbrain, and hindbrain.
The mesolimbic pathway, sometimes referred to as the reward pathway, is a dopaminergic pathway in the brain. [1] The pathway connects the ventral tegmental area in the midbrain to the ventral striatum of the basal ganglia in the forebrain. The ventral striatum includes the nucleus accumbens and the olfactory tubercle. [2]
The lateral hypothalamus is a portion of the hypothalamus, and brain stimulation to this area at the level of the medial forebrain bundle produces the highest response rates and subsequently the highest reward potency in rodents. Lesions in this region or along its boundary cause a loss of positive drive-reward behaviors as well as all other ...
The glutamatergic projection nuclei in the subthalamic nucleus, prefrontal cortex, hippocampus, thalamus, and amygdala connect to other parts of the reward system via glutamate pathways. [11] The medial forebrain bundle, which is a set of many neural pathways that mediate brain stimulation reward (i.e., reward derived from direct ...
The dopamine reward circuitry in the human brain involves two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. First, the posteromedial VTA and central linear raphe cells selectively project to the ventromedial striatum, which includes the medial olfactory tubercle and the medial NAC shell.
Other axons arising from these cells descend through the medial forebrain bundle to terminate in a region dorsal to the interpeduncular nucleus. The lateral septum is a relay center for connections from the CA3 of the hippocampus to the ventral tegmental area. [9] [10] These connections help link reward signals with the context in which they occur.
Incertohypothalamic pathway; Cerebral peduncle; Medial forebrain bundle; Medial longitudinal fasciculus; Myoclonic triangle; Solitary tract; Major dopaminergic pathways from dopaminergic cell groups. Mesocortical pathway; Mesolimbic pathway; Nigrostriatal pathway; Tuberoinfundibular pathway; Serotonergic pathways. Raphe Nuclei; Norepinephrine ...
The axons from dopamine neurons emanate from a primary dendrite and project ipsilaterally (on the same side) via the medial forebrain bundle to the dorsal striatum. There is a rough topographical correlation between the anatomical localization of the dopamine cell body within the SNc and the area of termination in the dorsal striatum.