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Dofetilide is a class III antiarrhythmic agent. [2] It is marketed under the trade name Tikosyn by Pfizer, and is available in the United States in capsules containing 125, 250, and 500 μg of dofetilide. It is not available in Europe [3] or Australia. [4]
Dofetilide blocks only the rapid K channels; this means that at higher heart rates, when there is increased involvement of the slow K channels, dofetilide has less of an action potential-prolonging effect. Sotalol is indicated for the treatment of atrial or ventricular tachyarrhythmias, and AV re-entrant arrhythmias.
dofetilide (Tikosyn) Antihistamines: terfenadine (Seldane) (off the market) diphenhydramine (partially) astemizole (off the market) Calcium channel antagonists: felodipine (Plendil) nicardipine (Cardene) nifedipine (Procardia) nimodipine (Nimotop) nisoldipine (Sular) isradipine (DynaCirc) Statins (HMG-CoA reductase inhibitors) simvastatin (Zocor)
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Bictegravir should not be used with dofetilide and rifampin. [16] Use of dofetilide with bictegravir increases the concentration of dofetilide, which can lead to life-threatening events. [ 16 ] Concomitant use of bictegravir and rifampin causes significant interactions because of an effect rifampin has on bictegravir. [ 16 ]
By Emma Rumney. WASHINGTON/LONDON (Reuters) -Alcoholic drinks should carry a warning about cancer risks on their label, the U.S. Surgeon General said on Friday in a move that could signal a shift ...
NEW ORLEANS ‒ On the booziest street in America, news that the Surgeon General thinks alcohol should come with warning labels is being met with a resounding "meh." Perhaps it's no surprise that ...