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HLA region of Chromosome 6. The human leukocyte antigen (HLA) system is a complex of genes on chromosome 6 in humans that encode cell-surface proteins responsible for regulation of the immune system. [1] The HLA system is also known as the human version of the major histocompatibility complex (MHC) found in many animals. [2]
HLA research didn't heat up until the 1980s when a group of researchers finally elucidated the shape of the HLA-A*02 protein (just one of many specific HLA proteins). [1] Even more recently, in 2010, the WHO committee responsible for naming all HLA proteins revised their standards for naming to introduce more clarity and specificity in the ...
HLA-A is a group of human leukocyte antigens (HLA) that are encoded by the HLA-A locus, which is located at human chromosome 6p21.3. [1] HLA is a major histocompatibility complex (MHC) antigen specific to humans. HLA-A is one of three major types of human MHC class I transmembrane proteins. The others are HLA-B and HLA-C. [2]
HLA-A1 (A1) is a human leukocyte antigen serotype within HLA-A "A" serotype group. The serotype is determined by the antibody recognition of α 1 subset of HLA-A α-chains. For A1, the alpha "A" chain are encoded by the HLA-A *01 allele group and the β-chain are encoded by B2M locus. [1] This group currently is dominated by A*01:01.
n/a Ensembl ENSG00000228964 ENSG00000234745 ENSG00000206450 ENSG00000224608 ENSG00000223532 ENSG00000232126 n/a UniProt P01889 n/a RefSeq (mRNA) NM_005514 n/a RefSeq (protein) NP_005505 n/a Location (UCSC) Chr 6: 31.35 – 31.37 Mb n/a PubMed search n/a Wikidata View/Edit Human HLA-B (major histocompatibility complex, class I, B) is a human gene that provides instructions for making a protein ...
Human leukocyte antigen (HLA) alleles associated with conditions of or affecting the human integumentary system Condition Associated HLA allele(s) Fixed drug eruption: B22 Lichen planus: DR1 DR2 DRw9 DR10 Bw15 B8 Psoriasis: Cw6 DR406 Psoriatic arthritis: B27 Ankylosing spondylitis: B27 Reactive arthritis: B27 Acute anterior uveitis: B27 Behçet ...
HLA-A25 (A25) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α 25 subset of HLA-A α-chains. For A25, the alpha "A" chain are encoded by the HLA-A *25 allele group and the β-chain are encoded by B2M locus. [1] This group currently is dominated by A*2501.
HLA-A26 (A26) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α 26 subset of HLA-A α-chains. For A26, the alpha "A" chain are encoded by the HLA-A *26 allele group and the β-chain are encoded by B2M locus. [1] This group currently is dominated by A*2601.