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This last form of the Hill equation is advantageous because a plot of versus [] yields a linear plot, which is called a Hill plot. [ 7 ] [ 8 ] Because the slope of a Hill plot is equal to the Hill coefficient for the biochemical interaction, the slope is denoted by n H {\displaystyle n_{H}} .
The first description of cooperative binding to a multi-site protein was developed by A.V. Hill. [4] Drawing on observations of oxygen binding to hemoglobin and the idea that cooperativity arose from the aggregation of hemoglobin molecules, each one binding one oxygen molecule, Hill suggested a phenomenological equation that has since been named after him:
The Hill equation can be used to describe dose–response relationships, for example ion channel-open-probability vs. ligand concentration. [9] Dose is usually in milligrams, micrograms, or grams per kilogram of body-weight for oral exposures or milligrams per cubic meter of ambient air for inhalation exposures. Other dose units include moles ...
Hill equation may refer to Hill equation (biochemistry) Hill differential equation This page was last edited on 28 ...
In biochemistry and pharmacology, the Hill and Hill–Langmuir equations are sigmoid functions. In computer graphics and real-time rendering, some of the sigmoid functions are used to blend colors or geometry between two values, smoothly and without visible seams or discontinuities.
The EC 50 represents the point of inflection of the Hill equation, beyond which increases of [A] have less impact on E. In dose response curves, the logarithm of [A] is often taken, turning the Hill equation into a sigmoidal logistic function. In this case, the EC 50 represents the rising section of the sigmoid curve.
Cooperativity is a phenomenon displayed by systems involving identical or near-identical elements, which act dependently of each other, relative to a hypothetical standard non-interacting system in which the individual elements are acting independently.
Hill plots (at least in older literature) are the primary way of measuring the parameters of the Hill equation. Currently Hill plots are not mentioned. I think searching on "Hill equation hemoglobin" leads to an underestimation of the importance of Hill plots: they can be used to describe the kinetics of any kind of molecule that binds to ...