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Severe side effects may include low blood pressure with standing, an irregular heart beat, and priapism. [2] [3] It is a selective α 1-adrenergic blocker in the quinazoline class of compounds. [2] Doxazosin was patented in 1977 and came into medical use in 1988. [4] It is available as a generic medication. [3]
Drug Adverse effects Cinchona bark Cinchona pubescens: Warfarin Possible additive effect [3] Chamomile: Blood thinners [23] Devil's Claw: grapple plant, wood spider Harpagophytum: Warfarin Additive effect [3] Ephedra Ephedra: Caffeine, decongestants, stimulants [15] Increases sympathomimetic effect of ephedra [3] Feverfew: featherfew Tanacetum ...
However, because there are several structural compositions that make each alpha blocker different, the side effects are different for each drug. Side effects that arise when taking alpha blockers can include the first dose effect, cardiovascular side effects, genitourinary side effects, as well as other side effects. [28]
Over the last 40 years, a variety of drugs have been developed from non-selective alpha-1 receptor antagonists to selective alpha-1 antagonists and alpha-1 receptor inverse agonists. [2] [3] The first drug that was used was a non-selective alpha blocker, named phenoxybenzamine and was used to treat BPH. [2]
Trodusquemine is an aminosterol (polyamine steroid conjugate) that inhibits protein tyrosine phosphatase 1B (PTP1B) activity. [1] The compound exhibits broad-spectrum antimicrobial activity [2] and numerous regenerative, neuroprotective, anti-atherosclerotic, antitumor, antiangiogenic, antiobesity, and anxiolytic properties. [3]
Common side effects include dizziness, headache, insomnia, nausea, blurry vision, and sexual problems. [9] [6] Other side effects may include feeling lightheaded with standing due to changes in blood pressure, and angioedema. [9] Tamsulosin is an alpha blocker and works by relaxing muscles in the prostate. [10]