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The classic Claisen condensation, a self-condensation between two molecules of a compound containing an enolizable ester. The mixed (or "crossed") Claisen condensation, where one enolizable ester or ketone and one nonenolizable ester are used.
It can be considered as a specific variation of the aldol condensation. This reaction is named after two of its pioneering investigators Rainer Ludwig Claisen and J. Gustav Schmidt, who independently published on this topic in 1880 and 1881. [1] [2] [3] An example is the synthesis of dibenzylideneacetone ((1E, 4E)-1,5-diphenylpenta-1,4-dien-3 ...
In organic chemistry, self-condensation is an organic reaction in which a chemical compound containing a carbonyl group (C=O) acts both as the electrophile and the nucleophile in an aldol condensation. It is also called a symmetrical aldol condensation as opposed to a mixed aldol condensation in which the electrophile and nucleophile are ...
Idealized scheme showing condensation of two amino acids to give a peptide bond. Many variations of condensation reactions exist. Common examples include the aldol condensation and the Knoevenagel condensation , which both form water as a by-product, as well as the Claisen condensation and the Dieckman condensation (intramolecular Claisen ...
Discovered (1887) the condensation reaction of an ester with an activated methylene group, now known as the Claisen condensation. Synthesis of cinnamates by reacting aromatic aldehydes with esters. The reaction is known as the Claisen reaction and was described by Claisen for the first time in 1890.
The Claisen rearrangement is a powerful carbon–carbon bond-forming chemical reaction discovered by Rainer Ludwig Claisen. [1] The heating of an allyl vinyl ether will initiate a [3,3]-sigmatropic rearrangement to give a γ,δ-unsaturated carbonyl, driven by exergonically favored carbonyl CO bond formation Δ(Δ f H) = −327 kcal/mol (−1,370 kJ/mol).
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An important product of the Fischer-Fink synthesis was ethyl 4,5-dimethylpyrrole-2-carboxylate, made from ethyl 2-oximinoacetoacetate and 2-methyl-3-oxobutanal, in turn made by the Claisen condensation of 2-butanone with ethyl formate. [12]