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Stimulants (also known as central nervous system stimulants, or psychostimulants, or colloquially as uppers) are a class of drugs that increase alertness. They are used for various purposes, such as enhancing attention, motivation, cognition, mood, and physical performance. Some stimulants occur naturally, while others are exclusively synthetic.
Because the drug usually contains a mix of uppers and downers, it is sometimes called a speedball. [6] Authorities [which?] are trying to educate potential users who may not know how different ketamine is from cocaine. Cocaine is a stimulant and ketamine is a sedative-hallucinogenic anesthetic. [7] It does not mix well with alcohol. [8]
In the late 1960s and early 1970s, Dexamyl spansules—a clear and green capsule containing green and white "beads"—became popular as a street-drug upper nicknamed "Christmas trees", a reference to its appearance. [6] In his autobiography My Life of Absurdity, author Chester Himes writes of his use of Dexamyl in the mid-1950s. He also writes ...
Speedball, powerball, or over and under [1] is the polydrug mixture of a stimulant with a depressant, usually an opioid.The most well-known mixture used for recreational drug use is that of cocaine and heroin; however, amphetamines can also be mixed with morphine and/or fentanyl.
Recreational drug use is the use of one or more psychoactive drugs to induce an altered ... wakefulness, and locomotion. Stimulants are also occasionally called "uppers".
Pharmaceutical compound Poppers A selection of over-the-counter poppers on display Clinical data Other names popper, poppe Routes of administration Inhalation Drug class Vasodilator Legal status Legal status AU: S4 (Prescription only) in general; some exceptions Elsewhere, usually available OTC Pharmacokinetic data Bioavailability When inhaled, Amyl nitrite: unknown Isopropyl nitrite: 43% ...
In contrast, stimulants, or "uppers", increase mental alertness, making stimulants the opposite drug class from depressants. Antidepressants are defined by their effect on mood, not on general brain activity, so they form an orthogonal category of drugs. Depressants are closely related to sedatives as a category of drugs, with significant ...
Amphetamine is a weak base with a pK a of 9.9; [3] consequently, when the pH is basic, more of the drug is in its lipid soluble free base form, and more is absorbed through the lipid-rich cell membranes of the gut epithelium. [3] [29] Conversely, an acidic pH means the drug is predominantly in a water-soluble cationic (salt) form, and less is ...