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Technetium (99m Tc) sestamibi is a lipophilic cation which, when injected intravenously into a patient, distributes in the myocardium proportionally to the myocardial blood flow. Single photon emission computed tomography imaging of the heart is performed using a gamma camera to detect the gamma rays emitted by the technetium-99m as it decays.
In the myocardial perfusion scans using 99m Tc, the radiopharmaceuticals 99m Tc-tetrofosmin (Myoview, GE Healthcare) or 99m Tc-sestamibi (Cardiolite, Bristol-Myers Squibb) are used. Following this, myocardial stress is induced, either by exercise or pharmacologically with adenosine , dobutamine or dipyridamole (Persantine), which increase the ...
By the late 1980s, two different compounds containing technetium-99m were introduced: teboroxime [10] and sestamibi. The utilization of Tc-99m would allow higher doses (up to 1,100 MBq or 30 mCi) due to the shorter physical (6 hours) half life of Tc-99m.
A cardiac specific radiopharmaceutical is administered, e.g., 99m Tc-tetrofosmin (Myoview, GE healthcare), 99m Tc-sestamibi (Cardiolite, Bristol-Myers Squibb) or Thallium-201 chloride. Following this, the heart rate is raised to induce myocardial stress, either by exercise on a treadmill or pharmacologically with adenosine , dobutamine , or ...
Perfusion stress test (with 99mTc labelled sestamibi [15]) is appropriate for select patients, especially those with an abnormal resting electrocardiogram. Intracoronary ultrasound or angiogram can provide more information but is invasive and carries the risk of complications associated with cardiac catheterization procedures.
The patient is placed under a gamma camera, which detects the low-level 140 keV gamma radiation being given off by Technetium-99m (99m Tc). As the gamma camera images are acquired, the patient's heart beat is used to 'gate' the acquisition. The final result is a series of images of the heart (usually sixteen), one at each stage of the cardiac ...
The metastable technetium-99m (99m Tc) is a short-lived (half-life about 6 hours) nuclear isomer used in nuclear medicine, produced from molybdenum-99. It decays by isomeric transition to technetium-99, a desirable characteristic, since the very long half-life and type of decay of technetium-99 imposes little further radiation burden on the body.
A sestamibi parathyroid scan is a procedure in nuclear medicine which is performed to localize parathyroid adenoma, which causes Hyperparathyroidism. [1] Adequate localization of parathyroid adenoma allows the surgeon to use a minimally invasive surgical approach.