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Transplant glomerulopathy is considered a form of chronic antibody-mediated rejection. PAS stain. Chronic rejection is an insidious form of rejection that leads to graft destruction over the course of months, but most often years after tissue transplantation. [12]
These antibodies can cause antibody-mediated rejection and are therefore considered a contraindication against transplantation in most cases. [1] DSA are a result of B cell and plasma cell activation and bind to HLA and/or non-HLA molecules on the endothelium [ 1 ] of the graft.
Immunoadsorption is also used in kidney transplantation for either the preparation of the ABO-incompatible or the highly sensitized kidney transplant candidate before transplantation, or the treatment of antibody-mediated rejection after transplantation. [8]
A kidney and stem cells from his sister Alex Hernandez was 27 when he received a kidney transplant and a dose of stem cells from his sister as one of Akkina’s patients and a trial participant.
Kidney transplant rejection can be classified as cellular rejection or antibody-mediated rejection. Antibody-mediated rejection can be classified as hyperacute, acute, or chronic, depending on how long after the transplant it occurs. If rejection is suspected, a kidney biopsy should be obtained. [5]
Out of all the suggested mechanisms, the one that has been documented the most is the correlation between donor-specific antibody against the human leukocyte antigen (anti-HLA-DSA), antibody-mediated mediated rejection (ABMR), and endothelial damage that results in the development of TG. [13]
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