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Technetium-99m (99m Tc) is a metastable nuclear isomer of technetium-99 (itself an isotope of technetium), symbolized as 99m Tc, that is used in tens of millions of medical diagnostic procedures annually, making it the most commonly used medical radioisotope in the world.
A nuclear pharmacist adds anywhere from 50 - 100 mCi of Na[99m TcO 4] to the reaction vial to make the final product, in the pH range of 3.8 to 8.0. After being allowed to react at room temperature for 15 minutes to ensure maximum labeling of the human albumin with 99m Tc, the kit can then be diluted with sterile normal saline as needed.
The metastable technetium-99m (99m Tc) is a short-lived (half-life about 6 hours) nuclear isomer used in nuclear medicine, produced from molybdenum-99. It decays by isomeric transition to technetium-99, a desirable characteristic, since the very long half-life and type of decay of technetium-99 imposes little further radiation burden on the body.
Today, Technetium-99m is the most utilized element in nuclear medicine and is employed in a wide variety of nuclear medicine imaging studies. Widespread clinical use of nuclear medicine began in the early 1950s, as knowledge expanded about radionuclides, detection of radioactivity, and using certain radionuclides to trace biochemical processes.
A DPD scan is a type of nuclear medicine imaging test which uses radioactive technetium-99m (99m Tc) and 3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) to diagnose cardiac amyloidosis. The radiopharmaceutical is taken up only in patients with ATTR amyloidosis, making it a useful tool to differentiate from AL amyloidosis. [1]
Radiopharmaceuticals are used in the field of nuclear medicine as radioactive tracers in medical imaging and in therapy for many diseases (for example, brachytherapy). Many radiopharmaceuticals use technetium-99m (Tc-99m) which has many useful properties as a gamma-emitting tracer nuclide.
In particular it is used to carry the 99m Tc isotope (half-life 6 hours) which is commonly used in nuclear medicine in several nuclear scanning procedures. Pertechnetate is poorly hydrated as [TcO 4 (H 2 O) n] − and [TcO 4 (H 2 O) n-m] − [H 3 O] + m (n = 1–50, m = 1–4) clusters that have been demonstrated by simulation with DFT.
Technetium (99m Tc) mertiatide is a radiopharmaceutical medication used in nuclear medicine to image the kidneys. [1] It is a renal imaging agent that is given by intravenous injection. [1] It was approved for medical use in the United States in June 1990. [2]