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Unlike high-content analysis, high-content screening implies a level of throughput which is why the term "screening" differentiates HCS from HCA, which may be high in content but low in throughput. In high content screening, cells are first incubated with the substance and after a period of time, structures and molecular components of the cells ...
Classical High throughput screening robotics are now being tied closer to cell biology, principally using technologies such as High-content screening.High throughput cell biology dictates methods that can take routine cell biology from low scale research to the speed and scale necessary to investigate complex systems, achieve high sample size, or efficiently screen through a collection.
In high-throughput screening (HTS), one of the major goals is to select compounds (including small molecules, siRNAs, shRNA, genes, et al.) with a desired size of inhibition or activation effects. A compound with a desired size of effects in an HTS screen is called a hit.
High-throughput screening (HTS) is a method for scientific discovery especially used in drug discovery and relevant to the fields of biology, materials science [1] and chemistry. [ 2 ] [ 3 ] Using robotics , data processing/control software, liquid handling devices, and sensitive detectors, high-throughput screening allows a researcher to ...
High-content screening where changes in the expression of several proteins can be simultaneously monitored is also often used. [ 9 ] [ 10 ] High-content imaging of dye-labeled cellular components can also reveal effects of compounds on cell cultures in vitro, distinguishing the phenotypic effects of a broad variety of drugs.
This research led to the development of reliable screening tools for substance use, such as the Michigan Alcohol Screening Test, the CAGE, and the Drug Abuse Screening Test. [ 10 ] Research also extended to understanding the best mode of administration of such screening assessments, as part of a clinician interview via a questionnaire, or ...
The extended questioning is a benefit in a sense that one accomplishes a bit of the assessment section when conducting the screening; furthermore, it allows the individual conducting the screening to achieve better communication and rapport with the client. [citation needed]
Print/export Download as PDF ... High-throughput may refer to: High-throughput computing, a computer science concept; High-throughput screening, a bioinformatics ...