Search results
Results From The WOW.Com Content Network
Microautophagy together with macroautophagy is necessary for nutrient recycling under starvation. Microautophagy due to degradation of lipids incorporated into vesicles regulates the composition of lysosomal/vacuolar membrane. [1] Microautophagic pathway functions also as one of the mechanism of glycogen delivery into the lysosomes. [2]
Although hsc70 targets cytosolic protein to CMA based on specific amino acid sequence recognition, it works differently when targeting proteins to macro or microautophagy. [3] In one mechanism for a protein to be a CMA substrate, it must have in its amino acid sequence a pentapeptide motif biochemically related to KFERQ. [4]
Autophagy (or autophagocytosis; from the Greek αὐτόφαγος, autóphagos, meaning "self-devouring" [1] and κύτος, kýtos, meaning "hollow") [2] is the natural, conserved degradation of the cell that removes unnecessary or dysfunctional components through a lysosome-dependent regulated mechanism. [3]
It is known that some viruses can modulate mitophagy (directly or indirectly) using different mechanisms and, as a result, cause a disbalance in the innate immune response. [21] mtDNA that exits damaged mitochondria acts as one of the triggers of type I interferon (IFN I) production. Some viruses can induce mitophagy and therefore inhibit the ...
mTORC1, also known as mammalian target of rapamycin complex 1 or mechanistic target of rapamycin complex 1, is a protein complex that functions as a nutrient/energy/redox sensor and controls protein synthesis.
340061 72512 Ensembl ENSG00000184584 ENSG00000288243 ENSMUSG00000024349 UniProt Q86WV6 Q3TBT3 RefSeq (mRNA) NM_001301738 NM_198282 NM_001367258 NM_001289591 NM_001289592 NM_028261 RefSeq (protein) NP_001288667 NP_938023 NP_001354187 NP_001276520 NP_001276521 NP_082537 Location (UCSC) Chr 5: 139.48 – 139.48 Mb Chr 18: 35.87 – 35.87 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse ...
The reaction mechanism of the Mitsunobu reaction is fairly complex. The identity of intermediates and the roles they play has been the subject of debate. Initially, the triphenyl phosphine (2) makes a nucleophilic attack upon diethyl azodicarboxylate (1) producing a betaine intermediate 3, which deprotonates the carboxylic acid (4) to form the ion pair 5.
3312 15481 Ensembl ENSG00000109971 ENSMUSG00000015656 UniProt P11142 P63017 RefSeq (mRNA) NM_006597 NM_153201 NM_031165 NM_001364480 RefSeq (protein) NP_006588 NP_694881 NP_112442 NP_001351409 Location (UCSC) Chr 11: 123.06 – 123.06 Mb Chr 9: 40.71 – 40.72 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Heat shock 70 kDa protein 8 also known as heat shock cognate 71 kDa protein ...