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All aminoglycosides can cause either reversible or irreversible ototoxicity. Ototoxicity is more frequently observed in individuals who received the treatment for more than five days and those who have renal insufficiency. [7] The mechanism of aminoglycosides-induced ototoxicity is not well understood.
Side-effects of amikacin are similar to those of other aminoglycosides. Kidney damage and ototoxicity (which can lead to hearing loss) are the most important effects, occurring in 1–10% of users. [17] The nephro- and ototoxicity are thought to be due to aminoglycosides' tendency to accumulate in the kidneys and inner ear. [8] Diagram of the ...
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Recent single-molecule tracking experiments in live E. coli showed an ongoing but slower protein synthesis upon treatment with different aminoglycoside drugs. [9] Spectinomycin , a related but distinct chemical structure class often discussed with aminoglycosides, does not induce mRNA misreading and is generally not bactericidal.) [ 8 ]
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A review by the Memorial Sloan Kettering Cancer Center found no evidence that the Hoxsey Therapy was effective as a treatment for cancer. [48] Issels treatment – a regime recommended to be used alongside conventional treatment. It requires removal of metal fillings from the patient's mouth, and adherence to a restrictive diet.
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[3] [11] [24] The trial was designed to compare the efficacy of pancreatic enzyme therapy plus a specialized diet with gemcitabine for stage II, stage III, or stage IV pancreatic cancer. [25] However, the study had difficulty attracting patients, [ 26 ] and most eligible patients refused random assignment, so the trial was changed in 2001 to a ...