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GI symptoms can occur up to 20 years prior to the onset of clinical motor symptoms. [10] [7] The potential involvement of the gut in PD was first suggested over 200 years ago by James Parkinson, who describes PD as “a disordered state of the stomach and bowels (that) may induce a morbid action in a part of the medulla spinalis”. [11]
Parkinson's Disease causes constipation and gastric dysmotility that is severe enough to endanger comfort and even health. [26] A factor in this is the appearance of Lewy bodies and Lewy neurites even before these affect the functioning of the substantia nigra in the neurons in the enteric nervous system that control gut functions. [27]
A new study has suggested that damage to the upper gastrointestinal tract from conditions such as reflux, peptic ulcers, and prolonged use of NSAIDS may increase Parkinson’s risk by 76%.
Parkinson's poses digestive problems like constipation and prolonged emptying of stomach contents, and a balanced diet with periodical nutritional assessments is recommended to avoid weight loss or gain and minimize the consequences of gastrointestinal dysfunction. In particular, a Mediterranean diet is advised and may slow disease progression.
If you deal with ulcers or other gastrointestinal issues, Chang says that you're not destined to be diagnosed with Parkinson’s disease. “Mucosal damage is more common than most people think ...
Clinical features mimic those seen with mechanical intestinal obstructions and can include abdominal pain, nausea, abdominal distension, vomiting, dysphagia and constipation [2] [3] depending upon the part of the gastrointestinal tract involved. It is a difficult condition to diagnose, requiring exclusion of any other mechanical cause of ...
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