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This is a list of investigational autism and pervasive developmental disorder drugs, or drugs that are currently under development for clinical use in the treatment of autistic spectrum disorders and/or other pervasive developmental disorders but are not yet approved.
Use of anticonvulsant medications should be carefully monitored during use in pregnancy. [94] For example, since the first trimester is the most susceptible period for fetal development, planning a routine antiepileptic drug dose that is safer for the first trimester could be beneficial to prevent pregnancy complications. [95]
VPA is an anticonvulsant drug commonly administered for generalized and partial seizures, but also for the treatment of migraines and bipolar mood disorder. Its mechanisms of action are varied, including enhanced GABA neurotransmission, modified inositol metabolism, and interaction with the ERK and Wnt/B-catenin signaling systems. [43]
An off-label prescription drug has been shown to help children with autism gain the ability to speak. Leucovorin is used for cancer patients, but doctors are pushing for its approval for autism.
Depakote (valproic acid/sodium valproate) – an antiepileptic and mood stabilizer used to treat bipolar disorder, neuropathic pain and others; sometimes called an antimanic medication. Depakene is the trade name for the same drug prepared without sodium. Desyrel – an atypical antidepressant used to treat depression and insomnia
More than half of U.S. children diagnosed with ASD are prescribed psychoactive drugs or anticonvulsants, with the most common drug classes being antidepressants, stimulants, and antipsychotics. [117] Only the antipsychotics have clearly demonstrated efficacy. [118]
Convulsant drugs (the functional opposites of anticonvulsants) will always induce seizures at sufficient doses. Examples of such agents — some of which are used or have been used clinically and others of which are naturally occurring toxins — include strychnine , bemegride , flumazenil , cyclothiazide , flurothyl , pentylenetetrazol ...
Aribit (Aripiprazole) tablets. Aripiprazole, sold under the brand name Abilify, among others, is an atypical antipsychotic [14] primarily used in the treatment of schizophrenia, bipolar disorder, and irritability associated with autism spectrum disorder; [14] other uses include as an add-on treatment for major depressive disorder and tic disorders. [14]