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An antiplatelet drug (antiaggregant), also known as a platelet agglutination inhibitor or platelet aggregation inhibitor, is a member of a class of pharmaceuticals that decrease platelet aggregation [1] and inhibit thrombus formation.
Glanzmann's thrombasthenia is an abnormality of the platelets. [2] It is an extremely rare coagulopathy (bleeding disorder due to a blood abnormality), in which the platelets contain defective or low levels of glycoprotein IIb/IIIa (GpIIb/IIIa), which is a receptor for fibrinogen.
ATP can be metabolised in cardiovascular tissues to pro-aggregatory ADP, AMP or adenosine. Replacement of anhydride oxygen between phosphorus β (Pβ) and phosphorus γ (Pγ) with di-Chloro or di-Fluoro-methylene leads to a compound that is equipotent to ATP and have a similar pKa. Because of this replacement the metabolism of ATP to pro ...
Thrombosis (from Ancient Greek θρόμβωσις (thrómbōsis) ' clotting ') is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.
The term thrombocyte (clot cell) came into use in the early 1900s and is sometimes used as a synonym for platelet; but not generally in the scientific literature, except as a root word for other terms related to platelets (e.g. thrombocytopenia meaning low platelets).
Misfolded proteins can form protein aggregates or amyloid fibrils, get degraded, or refold back to its native structure.. In molecular biology, protein aggregation is a phenomenon in which intrinsically-disordered or mis-folded proteins aggregate (i.e., accumulate and clump together) either intra- or extracellularly.
Diagram of T. gondii structure with dense granules. T. gondii contains organelles called unique organelles including dense granules. Dense granules, along with other secretory vesicles such as a microneme and rhoptry secrete proteins involved in the gliding motility, invasion, and parasitophorous vacuole formation of Toxoplasma gondii.
DI (Daerah Istimewa) - special region DIPIAD (Dinas Pusat Intelijen Angkatan Darat) Army Central Intelligence Service DI/TII/NII (Darul Islam/Tentara Islam Indonesia/Negara Islam Indonesia) - an extreme Muslim rebel group against Republic of Indonesia in West Java (1945–1963), led by Kartosoewiryo. Their main goal was establishing a Moslem ...