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Free light chains (FLCs) are immunoglobulin light chains that are found in the serum (blood) in an unbound (free) state. In recent decades, measuring the amount of free light chains (FLCs) in the blood has become a practical clinical test. FLC tests can be used to diagnose and monitor diseases like multiple myeloma and amyloidosis.
Once set, light chain class remains fixed for the life of the B lymphocyte. In a healthy individual, the total kappa-to-lambda ratio is roughly 2:1 in serum (measuring intact whole antibodies) or 1:1.5 if measuring free light chains, with a highly divergent ratio indicative of neoplasm. The free light chain ratio ranges from 0.26 to 1.65. [1]
ConsumerAffairs is an American customer review and consumer news platform that provides information for purchasing decisions around major life changes or milestones. [5] The company's business-facing division provides SaaS that allows brands to manage and analyze review data to improve their products and customer service.
Light chain deposition disease can affect any organ. [3] Renal involvement is always present and can be identified by microscopic hematuria and proteinuria.Due to the gradual buildup of light chains from plasma filtration, renal function rapidly declines in the majority of patients with LCDD as either acute tubulointerstitial nephritis or rapidly progressing glomerulonephritis.
Consumer Reports Best Buy Drugs is available free on Consumer Reports Health.org. It compares prescription drugs in over 20 major categories, such as heart disease, blood pressure and diabetes, and gives comparative ratings of effectiveness and costs, in reports and tables, in web pages and PDF documents, in summary and detailed form.
Mayo Clinic Proceedings is a monthly peer-reviewed medical journal published by Elsevier and sponsored by the Mayo Clinic. It covers the field of general internal medicine. The journal was established in 1926 as the Proceedings of the Staff Meetings of the Mayo Clinic and obtained its current name in 1964.
The number of independent pharmacies has been steadily declining over recent years [4] due to the difficulty of competing with large chain corporations. Large chains have the advantage of a vastly greater reach and an abundance of resources, and sometimes independent pharmacies cannot keep up with the level of production.
Statistical packages can calculate a standard score (Z-score) for Cohen's kappa or Fleiss's Kappa, which can be converted into a P-value. However, even when the P value reaches the threshold of statistical significance (typically less than 0.05), it only indicates that the agreement between raters is significantly better than would be expected ...